Publications

Integration of single-cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genes
Sukhatme MG, Kar A, Arasu UT, Lee SHT, Alvarez M, Garske KM, Gelev KZ, Rajkumar S, Das SS, Kaminska D, Männistö V, Peltoniemi H, Heinonen S, Säiläkivi U, Saarinen T, Juuti A, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P
medRxiv, 2024
Paper

Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue
Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna D, Alvarez M, Sukhatme MG, Gelev KZ, Heffel MG, Zhang Yi, Avram O, Rahmani E, Sankararaman S, Heionen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P
bioRxiv, 2024
Paper

Genome-wide Association Study of Long COVID
Lammi V et al.
Nature Genetics, 2023
Paper

A second update on mapping the human genetic architecture of COVID-19
The COVID-19 Host Genetics Initiative
Nature, 2023
Paper

Variants at adipocyte open chromatin act in cis and interact in trans on abdominal obesity risk
Sukhatme MG, Kar A, Arasu UT, Lee SHT, Alvarez M, Garske KM, Gelev KZ, Rajkumar S, Das SS, Kaminska D, Männistö V, Peltoniemi H, Heinonen S, Säiläkivi U, Saarinen T, Juuti A, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P
ASHG, 2024

Epistatic SNPs land in regulatory regions and possess a similar risk as GWAS SNPs in a common liver disease, MASLD
Kar A, Fu B, Sukhatme MG, Lee SHT, Border R, Garske KM, Chen Z, Kaminska D, Männistö V, Pihlajamäki J, Sankararaman S, Pajukanta P
ASHG, 2024

Single-cell level analysis of obese individuals’ two main fat depots discovers differences in cell-type marker genes and their genetic risks for obesity
Sukhatme MG, Arasu UT, Kar A, Lee SHT, Alvarez M, Selvarajan I, Örd T, Kaminska D, Männistö V, Pihlajamäki J, Kaikkonen MU, Pajukanta P
ASHG, 2023

Single Cell Multiomics Profiling of Visceral Adipose Tissue Reveals New Insights into the Genetic Regulation of Cardiometabolic Disease
Arasu UT, Selvarajan I, Örd T, Taipale M, Toropainen A, Sukhatme MG, Kar A, Lee SHT, Alvarez M, Kaminska D, Männistö V, Pihlajamäki J, Pajukanta P, Kaikkonen MU
ASHG, 2023